Disruption of β‐catenin/Tcf4 complex with β‐catenin/Tcf inhibitors such as PKF118‐310, PKF115‐584, or CGP049090 also interferes with the proliferation of cultured human HCC cells (HepG2 and Huh7) in vitro; it also inhibits tumor growth in vivo in the HepG2 xenograft model by inducing apoptosis as well as decreasing the expression of Myc and CCND1.64 This evidence concerns the gene MYC and hepatocellular carcinoma.