KRAS and neoplasm: In addition, evidences show mitochondrial metabolism and mitochondrial reactive oxygen species (ROS) generation are essential for Kirsten rat sarcoma viral oncogene homolog (KRAS)‐driven tumorigenicity,5 and mitochondria OXPHOS inhibition by small molecules targeting OXPHOS complex I and complex V induces tumor cell death and reduces tumor growth in animal models.6, 7, 8