ARG1 and neoplasm: Interestingly, TAMs enhance aerobic glycolysis, and exhibit a mixed phenotype of M1 and M2, with increased expression of pro‐inflammatory cytokines and chemokines, Arg1, IL4Ra, and M2 macrophage‐associated cytokines, which may be mediated to some extent by tumor‐derived lactate via Akt/mTOR signaling.62