It relocates pro-apoptotic BH3-only proteins, such as Bim, from anti-apoptotic Bcl-2 proteins, resulting in the induction of apoptosis.44 The present results suggest that senolytic activity by navitoclax is, at least in part, mediated by the inhibition of Bcl-xL in malignant meningioma cells under the combined treatment with gemcitabine and IR. The gene discussed is BCL2L1; the disease is Anaplastic (Malignant) Meningioma.