PLAUR also regulates and remodels the extracellular matrix and has been shown to promote in vitro GBM survival.17 The expression of PLAUR is the highest in the mesenchymal subtype of GBM and high expression also trends towards predicting poor survival in GBM patients (log HR = 0.7[0.49–1], log-rank P-value = .0515) (Figure 1E). Here, PLAUR is linked to glioblastoma.