Our conclusion of additional blockage at the step of viral post-entry nuclear migration came from multiple results: (1) The post-entry stimulation of resting CD4 T cells with CD2 did not block HIV latent infection (Figure S3), which is in great contrast to the strong inhibition of HIV by CD2 prestimulation (Figure 1), suggesting that CD2-mediated inhibition is likely limited to viral early infection steps such as viral entry and nuclear migration. The gene discussed is CD4; the disease is disease arising from reactivation of latent virus.