Surprisingly, when resting T cells were similarly prestimulated with the anti-CD2 antibody, we observed 90%–99% inhibition of HIV-1 latent infection of resting CD4 T cells (Figures 1A–1F); this CD2-mediated inhibition has been tested in a total of eight donors, and we observed strong inhibition in all donors tested. Here, CD4 is linked to disease arising from reactivation of latent virus.