CD2 and disease arising from reactivation of latent virus: However, contrary to the actin-associated viral DNA, the nuclear 2-LTR circles were highly diminished in the CD2-prestimulated cells (Figures 5A and S8), suggesting that CD2 prestimulation likely led to the retention of the viral pre-integration complex (PIC) in the cortical actin meshwork; the much higher amounts of viral nuclear DNA found in the CD2 un-stimulated control cells suggest successful viral PIC nuclear translocation for the latent infection of resting T cells.