Other top-enriched KEGG pathways included TNF, NF-κB, PI3k/Akt, NOD and Toll-like receptor signaling pathways (Figure 3F), which all play critical roles in liver fibrosis (Aoyama et al., 2010; Wang et al., 2015; Yang and Seki, 2015). This evidence concerns the gene AKT1 and Hepatic fibrosis.