TXN and neoplasm: Initially, mainly considered as thiol peroxidases to scavenge reactive oxygen species (ROS) under regular and stress conditions, their role in various cellular mechanisms with redox-dependent processes ranges from cell differentiation, tumor suppression, signal transduction, thioredoxin (TRX) oxidation and chaperone-dependent protein homeostasis to participation in stress resistance and disease control (Neumann et al., 2003; Jang et al., 2004; Hall et al., 2009; Yan et al., 2009; Vaseghi et al., 2018).