AKT1 and neoplasm: c-Met regulates multiple downstream signaling including STAT3/c-Myc/cyclin D1 [Figure 3], phosphatidylinositol 3-kinase (PI3K)/AKT serine/threonine kinase (AKT), Ras/mitogen- activated protein kinase (MAPK), Janus kinase (JAK)/signal transducer and activator of transcription (STAT) and Wnt/β-catenin to induce tumor cell proliferation and survival[43].