Besides, as further bimolecular mechanisms in the etiology of oral cancer, several studies reported the role of the epidermal growth factor (EGF), the mitogen-activated protein kinase (MAPK) pathway, the PI3K/AKT/mTOR pathway, the signal transducer and activator of transcription (STAT) pathway, TGF (transforming growth factor), NF-κB (nuclear factor κB), and Wnt/β-catenin [100–102]. This evidence concerns the gene EGF and lip and oral cavity carcinoma.