WFDC2 and interstitial lung disease: Of note, female gender (OR, 0.275; 95%CI, 0.085–0.893; p = 0.032), DAS28-ESR (OR, 0.821; 95%CI, 0.690–0.976; p = 0.026), and high levels of HE4 (OR, 9.080; 95%CI, 3.481–23.682; p < 0.001) persisted as independent risk factors for predicting RA-ILD (Table 5).