Recent evidence indicates that PPARγ dysfunction plays a crucial role in the excessive PASMC proliferation of hypoxic and other types of PAH (Ameshima et al., 2003; Kim et al., 2010; Xu et al., 2017), and further reveals the effect of PPARγ on anti-proliferation (Hansmann et al., 2008; Calvier et al., 2017, 2019). Here, PPARG is linked to pulmonary arterial hypertension.