Other experiments demonstrated that activation of PPARγ ligands by rosiglitazone attenuated pulmonary hypertension via suppressing oxidative, insulin resistance, and proliferative signals in mouse models treated with chronic hypoxia or apoE knockout mice fed a high-fat diet (Crossno et al., 2007; Hansmann et al., 2007; Nisbet et al., 2010). This evidence concerns the gene APOE and Insulin resistance.