Consistent with the results for distal PAs and PAECs from patients with PAH, Dec1 was elevated, but PPARγ was declined in a time-dependent manner when the cells were treated with serum deprivation (Figure 2C), H2O2 (Figure 2D), TGF-β1 (Figure 2E), and IL-6 (Figure 2F). This evidence concerns the gene BHLHE40 and pulmonary arterial hypertension.