PGLS and hepatocellular carcinoma: It also showed a lower NADP+/NADPH ratio, which was associated with the reduction of ROS production and apoptosis (Figures 2E–I), we next used scRNA-seq data to investigate the role of PGLS in HCC; we found that the expression of apoptosis-related genes was negative correlated with the expression of PGLS (Figure 2J).