Previous reports have shown that PGLS has a significant correlation with the occurrence of breast cancer, but its relationship with HCC has not been reported (Sivaraksa and Lowe, 2008), whereas Huh7 and Hep3b cell lines that knock down PGLS have decreased proliferation and metastasis and increased apoptosis in HCC cells. The gene discussed is PGLS; the disease is hepatocellular carcinoma.