We constructed two patient-derived xenograft (PDX) models with 4-HNE low (PDX #1) and 4-HNE high (PDX #2) (Figure 7K) and found that PKE inhibited tumor growth and FTL levels in the PDX #1 model to a greater extent than it did in the PDX #2 models (Figures 7L,M). The gene discussed is FTL; the disease is neoplasm.