To further elucidate the molecular mechanism of circ_0000215 modulating NPC progression, Gene Set Enrichment Analysis (GSEA) was executed using gene expression data from TCGA, and the data verified that high expression of PIK3R1 in NPC samples was positively linked to the activation of ERBB signaling (Figure 9A). The gene discussed is PIK3R1; the disease is nasopharyngeal carcinoma.