In the past few years, CRP, GPS, and CAR have been shown to have prognostic value in patients with hepatocellular carcinoma (Kinoshita et al., 2015) and gallbladder (Utsumi et al., 2020), pancreatic (Primavesi et al., 2020), ovarian (Liu et al., 2017), esophageal (Sakai et al., 2020), and gastric (Okugawa et al., 2020) cancers. The gene discussed is CRP; the disease is cancer.