TNF and congenital rubella syndrome: CAR-NK is less likely to induce CRS and neurotoxicity partially because of a different spectrum of secreted cytokines consisting of activated NK cells that produce IFN-gamma and GM-CSF, and CAR-T cells that predominantly release tumor necrosis factor (TNF)-a and interleukins, such as IL-1, IL-2, and IL-6 (57, 58).