Unpaired comparisons showed that HSPA1B (P<0.001), HSPA4 (P<0.001), HSPA5 (P<0.001), HSPA6 (P<0.001), HSPA8 (P<0.001), HSPA9 (P<0.001), HSPA13 (P<0.001), and HSPA14 (P<0.001) were upregulated in colon cancer and HSPA1A (P<0.001), HSPA2 (P<0.001), HSPA7 (P<0.01), and HSPA12B (P<0.001) were downregulated. The gene discussed is HSPA4; the disease is malignant colon neoplasm.