Results of our study showed that HSPA1B, HSPA4, HSPA5, HSPA6, HSPA8, HSPA9, HSPA13, and HSPA14 were upregulated, and those of HSPA1A, HSPA2, HSPA7, and HSPA12B were downregulated in colon cancer. This evidence concerns the gene HSPA8 and malignant colon neoplasm.