EGFR and neoplasm: In conclusion, these results revealed that imipramine not only suppressed the phosphorylation of EGFR/PKC-δ/NF-κB signaling and protein expression of NF-κB-mediated downstream proteins but also significantly induced the protein expression of apoptotic related proteins in CL1-5-F4/NF-κB-luc2 bearing mice tumor.