Genes down-regulated by FASN inhibition included cell cycle functions (mediated by cyclins, estrogen, and checkpoint proteins) and growth regulation (mediated by p53, PPAR, phospholipase C, p70 S6K, VEGF, IL2, IL22, GM-CSF, and HGF) as identified by the IPA analysis of all NHL cells (Figure 1C). The gene discussed is CSF2; the disease is non-Hodgkin lymphoma.