Among all variables analyzed, Binet stage (p < 0.001), the number of total T-cells (p < 0.001), CD4+ T-cells (p = 0.002), CD8+ T-cells (p = 0.001), basophils (p = 0.04), the size of the tumor B-cell clone in blood (p = 0.003), del(11q) and/or del(17p) (p = 0.04) and the number of cytogenetically altered CLL cells (p = 0.001) in addition to the hydropathy index of the HCDR3 sequences of the tumor B-cell clone (p < 0.001) all showed a prognostic impact in the univariate analysis (Table 3). Here, CD4 is linked to B-cell chronic lymphocytic leukemia.