BCR and B-cell chronic lymphocytic leukemia: In turn, B-cell activation via T-cell-dependent antigens leads to the expansion of hypermutated germinal center (GC)-derived B-cells (13), suggesting that M-CLL might be associated with the “classical unswitched memory B-cell” compartment, despite that some M-CLL also show BCR features that overlap with those of natural antibodies (14).