In this study, to investigate the mechanisms of KIT amelioration of stress-induced brain dysfunctions, we examined the effects of KIT on CORT-induced depression-like behavior, spatial memory impairment, and decreases in hippocampal cell survival, the number of hippocampal new-born immature neurons, hippocampal and accumbal dendritic spine density and mRNA for neurotrophic factors. Here, KIT is linked to major depressive disorder.