AGT and pulmonary arterial hypertension: We developed a computational model of PAAFs mechanosignaling that included TGFβ, MAPK, PDGF, tumor necrosis factor α (TNFα), hypoxia, fibroblast growth factor (FGF), angiotensin II, and Hippo signaling pathways, which are upregulated by PAH, and phenotypic outputs to investigate mechanical regulation of fibrosis in PAH (Wang et al. 2020).