We developed a computational model of PAAFs mechanosignaling that included TGFβ, MAPK, PDGF, tumor necrosis factor α (TNFα), hypoxia, fibroblast growth factor (FGF), angiotensin II, and Hippo signaling pathways, which are upregulated by PAH, and phenotypic outputs to investigate mechanical regulation of fibrosis in PAH (Wang et al. 2020). Here, TNF is linked to pulmonary arterial hypertension.