Cardiac conduction system specific ablation of DSP resulted in loss of CX45 and resulting sinus node dysfunction as well as the identification of human DSP mutations in sinus bradycardia patients, further reinforced DSP loss as an early driver of connexin-mediated arrhythmias in the absence of cardiomyopathy (Mezzano et al. 2016). Here, DSP is linked to cardiac arrhythmia.