However, electrical abnormalities (ventricular arrhythmias) associated with reduced CX43 cardiac cell junction localization could also be observed prior to fibro-fatty replacement in the myocardium in ARVC patients harboring DSP mutations (Gomes et al. 2012), extending this early crosstalk to the human myocardium. The gene discussed is DSP; the disease is Arrhythmogenic right ventricular dysplasia.