Interestingly, recent studies have drawn a connection between the desmosomal protein, DSG2, and mitochondrial-mediated calcium overload in ARVC in exercise settings via the calpain-1 pathway and shown that its inhibition can circumvent cardiomyocyte death by interfering with cleavage of apoptosis inducing factor (Chelko et al. 2021). The gene discussed is DSG2; the disease is Arrhythmogenic right ventricular dysplasia.