ARVC probands were found to express autoimmune biomarkers, which include organ specific and disease specific serum anti-heart autoantibodies (AHAs) and anti-intercalated disc autoantibodies (AIDAs) as well as desmosomal targeted anti-DSG2 autoantibodies at a higher level when compared to healthy controls (Chatterjee et al. 2018; Caforio et al. 2020). The gene discussed is DSG2; the disease is Arrhythmogenic right ventricular dysplasia.