Although SCN5A mutations (gene coding for Nav1.5) are directly linked to the inherited cardiac arrhythmia, Brugada syndrome (Wilde and Amin 2018), a retrospective analysis of Brugada patients identified that a subgroup of these patients harbored missense mutations in PKP2 (Cerrone et al. 2014). This evidence concerns the gene PKP2 and chronic obstructive pulmonary disease.