According to the data in this study, the anti-TB group and the antiviral group both demonstrated a significant rise on the ALT, AST, and TBIL after treatment, but the patients in the antiviral group were with much lower level of ALT, AST, and TBIL compared to the patients with antituberculosis therapy only, which revealed that the antiviral therapy with entecavir has significant influence on alleviating the liver injury. The gene discussed is GPT; the disease is tuberculosis.