In this study, whether in in vitro or in vivo experiments, patchouli alcohol can induce autophagy in NSCLC cells and has a significant regulatory effect on the key autophagy-related signaling pathway Akt/mTOR, while it has little effect on the phagocytic pathways of AMPK and MAPK, suggesting that patchouli alcohol may induce autophagy in NSCLC cells through the Akt/mTOR signaling pathway. This evidence concerns the gene MTOR and non-small cell lung carcinoma.