Platelets have been widely recognized as a component of the tumor microenvironment; the activation of platelets can release a variety of factors that regulate the tumor microenvironment, such as vascular endothelial growth factor (VEGF), TGFβ1, fibroblast growth factor (FGF), and proinflammatory cytokines, which can affect tumor growth, tumor metastasis, tumor angiogenesis, tumor inflammation, and chemotherapy efficiency [35–37]. The gene discussed is VEGFA; the disease is neoplasm.