Wnt3a is a Wnt protein that activates the canonical Wnt pathway and promotes colon cancer progression (Clevers, 2006; Qi et al., 2014), while all the Wnt3a mutations in three DSS-treated mucosae were deletion mutation (one is C deletion and other two is CT deletion) (Figure 3F). This evidence concerns the gene WNT3A and malignant colon neoplasm.