Alda-1 attenuated 4-HNE-induced vascular smooth muscle cell proliferation and migration by regulating NF-κB activation, ameliorated vascular remodeling in a mouse model of pulmonary hypertension and inhibited atherosclerosis and fatty liver in hyperlipidemic mice (30, 31). The gene discussed is NFKB1; the disease is pulmonary hypertension.