Nonproteinuric DN patients showed a significantly lower level of urinary NAG and a higher level of serum albumin compared with proteinuric DN patients (11.20 [9.00–14.50] U/L vs. 23.80 [13.70–54.00] U/L, p<0.05; 41.11 ± 3.61 g/L vs. 32.65 ± 5.81 g/L, p<0.001, respectively). The gene discussed is ALB; the disease is liver dysplastic nodule.