In our study, leptin levels were measured in 10 patients with PPARG-DM (3 with variants in non-AF1 domains and 7 with the p.Tyr95Cys variant); no differences were observed between PPARG-DM and T2DM, and only 1 patient with p.Tyr95Cys had low leptin levels (Table 2). Here, PPARG is linked to diabetes mellitus.