Only one study has reported the prevalence of rare variants of PPARγ2 in East Asians (19) by the exon sequencing of nearly 20,000 individuals (9,070 patients with T2DM and 10,682 controls) from multiethnic populations; in this previous study, 0.1% of individuals with T2DM carried functional rare variants of PPARγ2. Of note, only 998 patients with T2DM and 1,146 controls from East Asian populations (Korea and Singapore) were included in this study, and it is not clear whether the rare pathogenic variants of PPARγ2 existed in East Asian subpopulations. The gene discussed is PPARG; the disease is type 2 diabetes mellitus.