In the context of multidomain interventions, the Prevention of Dementia by Intensive Vascular Care (preDIVA) trial (55), the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) (56), and the Multidomain Alzheimer Preventive Trial (MAPT) (57) have investigated the modifying effect of ApoE status in response to the intervention. Here, APOE is linked to dementia.