Finally, 35 corresponding targets were found to be therapeutic targets against hepatic and renal fibrosis, among which the most critical targets were IL-1β, MAPK14, PTGS2, mTOR, MAPK8, MMP13, MMP1, MMP9, MAPK1, STAT3, TNF, EGFR, VEGFA, and MMP2. The gene discussed is IL1B; the disease is renal fibrosis.