Complete blockage of TNF-induced NF-κB activation in conditional deletion animals resulted in massive hepatocyte apoptosis after LPS injection (Luedde et al., 2007; Inokuchi et al., 2010), while inhibition of NF-κB in Kupffer cells or hepatic stellate cells led to a decrease in the severity of liver fibrosis both in chronically injured animals and patients with hepatitis C virus (Son et al., 2007; Oakley et al., 2009). This evidence concerns the gene TNF and Hepatic fibrosis.