In this study, we observed an elevation in the production of collagen fibers in interstitial and perivascular of RV, concomitant with a significant increase in the levels of myocardial fibrosis markers such as collagen I, III, and α-SMA, suggesting that myocardial fibrosis also plays a pivotal role in the process of RV remodeling. The gene discussed is ACTA1; the disease is Myocardial fibrosis.