Besides, in vitro infection of BV2 microglia cell line with DENV resulted in increased expression of proinflammatory cytokines, including IFN-γ, TNF-α, IL-6, IL-1β, IL-10, and monocyte chemoattractant protein-1 (MCP-1), as well as matrix metalloproteinase- (MMP-) 2 and MMP-9 (Bhatt et al., 2015). This evidence concerns the gene CCL2 and infection.