In our previous study, we also provided that the potential of flavonoids, terpenes/terpenoids, chalcones, and alkaloids has been shown in targeting angiotensin-converting enzyme 2 (ACE2) and spike proteins against neurological signs of coronavirus disease 2019 (COVID-19) and found promising results in combating pathophysiological mechanisms of the virus. The gene discussed is ACE2; the disease is COVID-19.