DDIT3 and diabetes mellitus: The expressions of endoplasmic reticulum stress-associated proteins, including glucose-regulated protein (GRP78), C/EBP-homologous protein (CHOP), and caspase-12, are incremented in diabetic heart tissues, while H2S suppresses diabetes-induced endoplasmic reticulum stress and abrogates myocardial hypertrophy and myocardial collagen deposition in diabetic rats (Li et al., 2016).