The blood pressure lowering effects of exogenous H2S donors have been demonstrated in spontaneous hypertensive rats (Ahmad et al., 2014; Li et al., 2019a), angiotensin II-induced hypertension (Al-Magableh et al., 2015; Hsu and Tain, 2018; Chi et al., 2019), Nw-nitro-l-argininemethyl ester (l-NAME)-induced hypertension (Ji et al., 2014; Jin et al., 2017), and renovascular hypertension (Guo et al., 2017a; Feng et al., 2020). This evidence concerns the gene AGT and Hypertension.