Consistent with this finding, NaHS prevents cardiac hypertrophy/fibrosis and ameliorates left ventricular dysfunction in STZ-induced diabetic rats by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway, accompanied by upregulations of antioxidant proteins haem oxygenase-1 (HO-1) and Nad(p)h: quinone oxidoreductase 1 (NQO1) in myocardium tissues from diabetic rats (Zhou et al., 2015). The gene discussed is NQO1; the disease is cardiac hypertrophy.