In addition, inactivation of Wnt/β-catenin signaling pathway and the signal transducer and activator of transcription 3 (STAT3)/hypoxia-inducible factor-1α (HIF-1α) pathway, upregulations of HO-1 and NQO1, induction of forkhead box O1 (FoxO1) phosphorylation and nuclear exclusion, are proposed to be main mechanisms for H2S donors to attenuate hyperglycemia-induced myocardial apoptosis and oxidative stress (Ye et al., 2018; Li et al., 2019b; Zhang and Ye, 2019). The gene discussed is FOXO1; the disease is Hyperglycemia.