Among these molecules, different studies reported the presence of potential biomarkers directly correlated with PD onset, including heme-oxygenase-1 and cysteine protease DJ-1 (Kang et al., 2014; Bäckström et al., 2015; Song et al., 2018; Bougea et al., 2019). This evidence concerns the gene HMOX1 and Parkinson disease.