For molecular mechanisms, previous studies have found that NRF2 inhibits LPS-activated inflammation by inhibiting the HO-1-mediated p65-p300 signaling pathway in BV2 microglia [35], and inhibition of NRF2 can reduce kidney inflammation in mice by limiting the activation of oxidative stress and NF-κB signaling pathways [36]. This evidence concerns the gene NFKB1 and nephritis.