Of the candidates, Bub1 was chosen for further study due to the role it plays in proliferation in other diseases, as aberrant Bub1 expression has been shown to promote cell proliferation in several cancers [33, 43, 62], and higher Bub1 expression in lipedema tissue and ADSCs could disrupt G1/S checkpoint inhibition resulting in increased cell proliferation. This evidence concerns the gene BUB1 and Lipedema.