Due to significant differences in plasma NFL concentrations and survival between spinal onset and bulbar onset ALS patients, a scatterplot revealed a significant negative correlation between plasma NFL levels and survival for patients with spinal onset ALS (ρ = −0.349, p < 0.0001) and bulbar onset ALS (ρ = −0.472, p < 0.0001) (Fig. 3A). The gene discussed is NEFL; the disease is amyotrophic lateral sclerosis.