Subgroup analysis of types of infection demonstrated a higher mean CRP level in patients with uncomplicated malaria than in febrile/healthy controls in studies of patients with P. falciparum (p < 0.001, SMD: 3.29, 95% CI: 1.86–4.71, I2: 95.7%, five studies) and studies of patients with P. falciparum/P. The gene discussed is CRP; the disease is malaria.