Altogether, in spite of the fact that several studies associated the therapeutic inhibition of angiogenesis with increased tumor cell invasiveness54, our data suggested that by codelivering LCL-SIM together with LCL-DMXAA, the tumor beneficial association between the activation of HIF-1α/VEGF axis and MMP-2/9 activation55,56 was blunted. This evidence concerns the gene VEGFA and neoplasm.