These are EGFR, ERRFI1, IL6, JAK2, PLXNC1, RGL3 which were found to be upregulated and CBL, CDC42, PIK3R3, STAT3, UBE2D2 and YWHAZ which were found to be downregulated; Melanoma has PLXNC1 as upregulated and TGFA as downregulated gene. The gene discussed is UBE2D2; the disease is melanoma.