Co-expressed genes linkage analysis of Bladder cancer, Endometrial cancer, Melanoma and Non-small cell lung cancer revealed nine potential genes viz EGFR, ERRFI1, GAB2, JAK2, IL6, PIK3R1, PLXNC1, RGL3, SPRY2 were upregulated and seven genes viz CBL, CDC42, PIK3R3, STAT3, TGFA, UBE2D2, YWHAZ were downregulated. This evidence concerns the gene SPRY2 and endometrial cancer.