Co-expressed genes linkage analysis of Bladder cancer, Endometrial cancer, Melanoma and Non-small cell lung cancer revealed nine potential genes viz EGFR, ERRFI1, GAB2, JAK2, IL6, PIK3R1, PLXNC1, RGL3, SPRY2 were upregulated and seven genes viz CBL, CDC42, PIK3R3, STAT3, TGFA, UBE2D2, YWHAZ were downregulated. The gene discussed is PIK3R3; the disease is melanoma.