Furthermore, BRCA cases did not differ from controls in terms of PAM50 proliferation score, GeparSixto immune activation signature score, CIN70 score, or TIMER-based relative abundance of tumor-infiltrating B cells, CD4 + T-cells, CD8 + T-cells, neutrophils, macrophages, or dendritic cells (Table 2). This evidence concerns the gene CD8A and invasive breast carcinoma.