None of the gene sets demonstrated significant differences between BRCA cases and controls after multiple test correction and only seven gene sets demonstrated nominal (p < 0.10) association with BRCA cases: WNT/Beta-catenin signaling (Hallmark), two neutrophil gene sets (IRIS), and two memory B-cell gene sets (IRIS) (Supplementary Tables 3 and 4). This evidence concerns the gene CTNNB1 and invasive breast carcinoma.