The network recovers the PTEN and TP53 modules as well as the Hippo pathway, the aryl hydrocarbon receptor complex (AHR/ARNT), the mTOR-repressing GATOR1 complex, the STAGA chromatin remodeling complex, JAK-STAT signaling, and the gamma-secretase complex (Fig. 2c and Supplementary 4c), all of which have been associated with tumor suppressor activity. This evidence concerns the gene PTEN and neoplasm.