ACACA and acute myeloid leukemia: Strikingly, all gene pairs within the fully connected clique in the FAS cluster (containing genes FASN, ACACA, GPAT4, CHP1, GPI CERS6, PCGF1, Fig. 2c) had a median Pearson correlation coefficient (PCC) of 0.76 in the 23 AML cell lines (range 0.63–0.95, Fig. 3a, red), compared to the median correlation of 0.05 in the remaining 785 cell lines (range −0.11–0.62, with the highest correlation between FASN and ACACA, adjacent enzymes in the linear palmitate synthesis pathway; Fig. 3a, gray).