Within hematological cancer cell lines, the coessentiality network is significantly restructured, with the ACACA/FASN module correlated with SCD in most backgrounds (r = 0.35, P < 10−18) but strongly anticorrelated in 36 blood cancer cell lines (r = −0.52, P < 10−3, Fig. 3e). Here, ACACA is linked to Schnyder corneal dystrophy.