MTOR and neoplasm: PTEN co-occurs with mTOR regulators NF250 (P < 3 × 10−11, Fisher’s exact test) and the TSC1/TSC2 complex (P values both <7 × 10−13)51, as well as Programmed Cell Death 10 (PDCD10)52, a proposed tumor suppressor7,53 (Fig. 2a).