Both M1 and M2 signature genes were markedly upregulated in Scnn1b-Tg AMs (Fig. 2e), and genes related to muco-obstructive lung diseases such as CF, COPD, and asthma, were positively enriched in Scnn1b-Tg AMs (Fig. 2e and Supplementary Fig. 3b). This evidence concerns the gene SCNN1B and asthma.