This included coherently hypomethylated loci with increased accessibility in Scnn1b-Tg AMs for genes involved in cytokine signaling, such as Tank, Il1r1, or the negative regulator Smurf1, as well as genes previously shown to be associated with chronic lung diseases (e.g., Infgr2, Zfp704, and Sec14l1) (Fig. 1i and Supplementary Fig. 2b)31–33. This evidence concerns the gene IL1R1 and chronic lung disease.