HRAS and neoplasm: We also performed whole exome sequencing (WES) or whole genome sequencing (WGS) on a subset of 26 tumor samples that have available DNA, and identified mutations in nine canonical driver genes, including BRAF, EGFR, ERBB2, HRAS, KRAS, MAP2K1, MET, NF1 and ROS13, while driver mutations in EGFR and KRAS mutation were detected in only six tumor samples (Fig. S3).