In addition, we identified genes of previously unknown cancer relevance with regards to leukemia circulation (e.g., LRIF1, DNAJC1, and CMC2) and therapeutic treatment (e.g., EBPL, MESDC2, ZRANB2, GTF2A2) (Figs. 1, 2, and 5). This evidence concerns the gene ZRANB2 and cancer.