CDH1 and acute myeloid leukemia: In TSC2−/− AML organoids, the analysis confirmed that the cells conforming the lining of the cysts stained positive for CDH1 and/or LTL, but not for PODXL1, indicating that similar to what is observed in TSC patients35 the cysts are specifically associated with tubular nephron segments, but can also emerge from multiple segments (Fig. 4f, Supplementary Fig. 5c, d).