TP53 and cancer: Importantly, across all the 61 cancer driver genes we analyzed above from Vogelstein et al.26, KRAS and p53 are the only ones showing such a significant difference in Cas9 activity between WT and mutant cells after FDR correction (FDR = 9.1E−04 for KRAS and 7.1E−06 for p53, Wilcoxon Rank-Sum test, Fig. 6e).